主要项目：
1.山东省自然科学基金青年科学基金（B）类项目，微生物环境信号感应与功能调控，2025.10-2028.09，主持
2.国家自然科学基金面上项目，微生物中具有dCache结构域的吲哚结合受体的发现、功能研究及应用探索，2024.1-2027.12，主持
3.山东省自然科学基金面上项目，肠道罗斯拜瑞氏菌Cache型趋化受体的配体筛选及功能研究，2025.1-2027.12，主持
4. 国家自然科学基金面上项目，基于杂交受体构建策略的胃肠道病原菌趋化受体的配体发现及功能研究，2021.01-2024.12，主持
5. 泰山学者青年专家计划，2020.01-2024.12，主持
6.山东大学齐鲁青年学者建设经费，2019.09-2024.08，主持
代表性论文：
1.Wang,X., Xu,W., Yao,F., Liu,S., Zhang,Y., Sourjik,V.*,Bi,S.*Discovery of an indole-sensing chemoreceptor inHelicobacter pylori. Curr. Biol., 2025. (In Press)
2.Bi,S., Kargeti, M, Colin, R., Farke, N., Link, H., Sourjik, V. Dynamic fluctuations in a bacterial metabolic network.Nat. Commun., 2023, 14:2173.
3. Duan, J., Zhao, Q., Wang, Y., Chi, Z., Li, W., Wang, X., Liu, S.,Bi, S.* The dCache domain of the chemoreceptor Tlp1 inCampylobacter jejunibinds and triggers chemotaxis toward formate.mBio, 2023,14(3):e0356422.
4.Liu, J., Wang, Y., Zhou, Y., Wang, X.,Bi,S.*Functional characterization of the methyl-accepting chemotaxis proteins RS10830 and RS10815 inXanthomonas oryzaepv.oryzicola.Int. J. Biol. Macromol., 2025, 306:141800.
5.Chen, H., Wang, Y., Li, D., Liu, C.Bi, S.*, Jiang, C.*, Liu, S.* Chemoreceptors from the commensal gutRoseburia rectibacterbind to mucin and trigger chemotaxis.Environ. Microbiol., 2023,25(7):1329-1343.
6.Zhao,Q.,Yao,F.,Li,W.,Liu,S.,Bi,S.*Identification of a dCachetype chemoreceptor inCampylobacter jejunithat specifically mediates chemotaxis towards methylpyruvate,Front.Microbiol., 2024, 15:1400284.
7. Chen, X.1,Bi, S.1,*, Ma, X., Sourjik, V., Lai, L.* Discovery of a new chemoeffector forEscherichia colichemoreceptor Tsr and identification of a molecular mechanism of repellent sensing.ACS BIO & MED CHEM Au, 2022, 2:386-394.
8.Bi, S.1, Jin, F.1, Sourjik, V. Inverted signaling by bacterial chemotaxis receptors.Nat. Commun., 2018, 9:2927.
9.Bi, S., Sourjik, V. Stimulus sensing and signal processing in bacterial chemotaxis.Curr. Opin. Microbiol., 2018, 45:22-29.
10.Bi, S., Pollard, A. M., Yang, Y., Jin, F., Sourjik, V. Engineering hybrid chemotaxis receptors in bacteria.ACS Synth. Biol.,2016, 5:989-1001.
11.Bi, S., Lai, L. Bacterial chemoreceptors and chemoeffectors.Cell. Mol. Life Sci., 2015, 72:691-708.
12.Bi, S., Yu, D., Si, G., Luo, C., Li, T., Ouyang, Q., Jakovljevice, V., Sourjik, V., Tu, Y., Lai, L. Discovery of novel chemoeffectors and rational design ofEscherichia colichemoreceptor specificity.Proc. Natl. Acad. Sci. U.S.A., 2013, 110:16814-16819.
