医药微生物技术

刘世恒

教授
博士/硕士生导师
个人简介 科研项目 学术论文 其他介绍

教育背景:

2009.09-2014.12 山东大学 博士 微生物学

2005.09-2009.07 山东大学 本科 生物科学


工作经历:

2025.09-至今 山东大学 教授

2021.02-2025.08 加州大学洛杉矶分校 项目科学家

2016.02-2021.02 加州大学洛杉矶分校 博士后


研究方向:

mRNA成熟的分子机制

主要项目:

1.国家海外高层次青年人才项目,2025-至今,主持

2.山东省泰山学者(青年项目),2025-至今,主持

代表性论文:*contribute equally

1.Shiheng Liu*, Tiantian Su, Xian Xia, Z. Hong Zhou (2025) Native DGC Structure Rationalizes Muscular Dystrophy-Causing Mutations. “Nature”.637(8048): 1261-1271.PMID: 39663457

2.Shiheng Liu*, Hong Wang*, Xiaorun Li, Fan Zhang, Jane K.J. Lee, Zihang Li, Clinton Yu, Jason J. Hu, Xiaojing Zhao, Takuma Suematsu, Ana L. Alvarez-Cabrera, Qiushi Liu, Liye Zhang, Lan Huang, Inna Aphasizheva, Ruslan Aphasizhev† and Z. Hong Zhou† (2023) Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. “Science”, 381: eadg4725.PMID: 37410820

3.Shiheng Liu*, Xian Xia*, and Z. Hong Zhou (2023) Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission. “Nat Commun”.PMID: 36797290

4.Fumiaki Ito, Ana L. Alvarez-Cabrera,Shiheng Liu, Hanjing Yang, Anna Shiriaeva, Z. Hong Zhou†, Xiaojiang S. Chen†(2023) Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase. “Sci Adv”, 9(1): eade3168.PMID: 36598981

5.Shiheng Liu*, Xian Xia*, James Zhen*, Zihang Li, Z. Hong Zhou (2022) Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney. “Cell Discov”, 8(1):126.PMID: 36414632

6.Xian Xia*,Shiheng Liu*, and Z. Hong Zhou (2022) Structural basis of ankyrin complex assembly on human red blood cell membrane. “Nat Struct Mol Biol”, 29(7):698-705.PMID: 35655099

7.Yuan Yang*,Shiheng Liu*, Sylvain Egloff, Catherine D. Eichhorn, Tanya Hadjian, James Zhen, Tamás Kiss, Z. Hong Zhou†, and Juli Feigon† (2022) Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP. “Mol. Cell”.PMID: 35320752

8.Nathan J. Hardenbrook*,Shiheng Liu*, Kang Zhou*, Z. Hong Zhou, Bryan A. Krantz(2020)Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. “Nat Commun”.PMID:32047164.

9.Kang Zhou*,Shiheng Liu*, Nathan J. Hardenbrook*, Yanxiang Cui, Bryan A. Krantz, Z. Hong Zhou(2020)Atomic structures of anthrax prechannel bound with full-length lethal and edema factors.“Structure”, 28(8):879-887.e3.PMID: 32521227

10.Xueni Li*,Shiheng Liu*, Lingdi Zhang, Aaron Issaian, Ryan C. Hill, Sara Espinosa, Shasha Shi, Yanxiang Cui, Kalli Kappel, Rhiju Das, Kirk C. Hansen, Z. Hong Zhou, Rui Zhao(2019)A unified mechanism for intron and exon definition and back-splicing.“Nature”, 573(7774):375-380.PMID: 31485080

11.Somsakul P. Wongpalee*,Shiheng Liu*, Javier Gallego-Bartolomé*, Alexander Leitner, Ruedi Aebersold, Wanlu Liu, Linda Yen, Maria A. Nohales, Peggy Hsuanyu Kuo, Ajay A. Vashisht, James A. Wohlschlegel, Suhua Feng, Steve A. Kay, Z. Hong Zhou, and Steve E. Jacobsen(2019)CryoEM Structures of Arabidopsis DDR Complexes Involved in RNA-directed DNA Methylation. “Nat Commun”.PMID: 31477705

12.Kalli Kappel,Shiheng Liu, Kevin P. Larsen, Georgios Skiniotis, Elisabetta Viani Puglisi, Joseph D. Puglisi, Z. Hong Zhou, Rui Zhao, Rhiju Das (2018)De novo computational RNA modeling into cryoEM maps of large ribonucleoprotein complexes.“Nature methods”, 15(11):947-954.PMID: 30377372

13.Shiheng Liu*, Xueni Li*, Lingdi Zhang, Jiansen Jiang, Ryan C. Hill, Yanxiang Cui, Kirk C. Hansen, Z. Hong Zhou, Rui Zhao(2017)Structure of the yeast spliceosomal post-catalytic P complex. “Science”, 358(6368):1278-1823.PMID: 29146870

14.Xueni Li*,Shiheng Liu*, Jiansen Jiang*, Lingdi Zhang, Sara Espinosa, Ryan C. Hill, Kirk C. Hansen, Z. Hong Zhou, Rui Zhao(2017)CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.“Nat Commun”, 8(1):1035.PMID: 29051543

15.Joyce J. W. Wong, Tracy A. Young, Jiayan Zhang,Shiheng Liu, George P. Leser, Elizabeth A. Komives, Robert A. Lamb, Z. Hong Zhou, Joshua Salafsky, Theodore S. Jardetzky (2017)Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation. “Nat Commun”, 8(1):781.PMID: 28974687

获奖情况:

2019 Boyer/Parvin Postdoctoral Awards


人才称号:

1.国家海外高层次青年人才

2.山东省泰山学者青年专家

3.山东省海外高层次青年人才

4.山东大学杰出中青年学者(第一层次)