教育背景:
2008.09-2012.07 山东大学 生物技术 学士
2012.09-2018.07 山东大学 微生物学 博士
工作经历:
2018.07-2024.06 微生物技术研究院 博士后
2024.07-2025.01 微生物技术研究院 科研助理
2025.02-至今 微生物技术研究院 助理研究员
研究方向:
黏细菌高效遗传操作体系的开发
黏细菌底盘的构建与应用
抗肿瘤药物埃博霉素的应用基础研究
主要项目:
国家自然科学基金青年项目,2024.01-2026.12
国家重点研发计划“绿色生物制造”重点专项子课题,2021.07-2025.06
山东省自然科学基金青年项目,2019.07-2022.06
中国博士后科学基金面上项目,2019.01-2020.12
代表性论文:
1.Kang X, Yeu XR, Wang CX, Zhu YN, Li YZ,Yue XJ#.Ribosome engineering ofMyxococcus xanthusfor enhancing the heterologous production of epothilones.Microbial Cell Factories.2024(独立通讯,本科生一作)
2.Yue XJ#, Wang JR, Zhao JN, Pan Z, LiYZ#. Determination of the chromosomal position effects for plug-and-play application in the Myxococcus xanthus chassis cells.Synthetic and Systems Biotechnology. 2024.(独立一作)
3.Hu WF, Wang Y, Yue XR, Xue WW, Hu W,Yue XJ#, Li YZ#.An upgradedMyxococcus xanthuschassis with enhanced growth characteristics for efficient genetic manipulation.Engineering Microbiology. 2024.(并列通讯)
4.Yuan SF,Yue XJ#, Hu WF, Wang Y, Li YZ#.Genome-wide analysis of lipolytic enzymes and characterization of a high-tolerant carboxylesterase fromSorangium cellulosum.Frontiers in Microbiology. 2023.(并列通讯)
5.Yue XJ#, Sheng DH, Zhuo L, Li YZ#.Genetic manipulation and tools in myxobacteria for the exploitation of secondary metabolism.Engineering Microbiology. 2023.(一作并通讯)
6.Wang Y,Yue XJ#, Yuan SF, Hong Y, Hu WF, Li YZ#.Internal promoters and their effects on the transcription of operon genes for epothilone production inMyxococcus xanthus.Frontiers in Bioengineering and Biotechnology. 2021.(并列通讯)
7.Yue XJ#, Cui XW, Zhang Z, Hu WF, Li ZF, Zhang YM, Li YZ#. Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones inMyxococcus xanthus.Appl Microbiol Biotechnol. 2018.(并列一作,并列通讯)
8.Yue XJ, Cui XW, Zhang Z, Peng R, Zhang P, Li ZF, Li YZ#. A bacterial negative transcription regulator binding on an inverted repeat in the promoter for epothilone biosynthesis.Microbial Cell Factories. 2017.(独立一作)
9. Hu WF, Yang JY, Wang JJ, Yuan SF,Yue XJ, Zhang Z, Zhang YQ, Meng JY, Li YZ#. Characteristics and immune functions of the endogenous CRISPR-Cas systems in myxobacteria.mSystems. 2024.
10. Hu WF, Niu L,Yue XJ, Zhu LL, Hu W, Li YZ#.,Wu CS#. Characterization of constitutive promoters for the elicitation of secondary metabolites in myxobacteria.ACS Synthetic Biology. 2021.
11. Zhang P, Zhang LJ,Yue XJ, Tang YJ, Wu CS#, Li YZ#. Effects of glycosylation on the bioactivity of rapamycin.Applied Microbiology and Biotechnology. 2020.
12. Sheng DH, Wang YX, Qiu M, Zhao JY,Yue XJ, Li YZ#. Functional Division Between the RecA1 and RecA2 Proteins in Myxococcus xanthus.Frontiers in Microbiology. 2020.
13. Zhang P, Zhang Z, Li ZF, Chen Q, Li YY, Gong Y,Yue XJ, Sheng DH, Zhang YM, Wu C#, Li YZ#. Phylogeny-guided characterization of glycosyltransferases for epothilone glycosylation.Microbial Biotechnology. 2019.
14. Peng R, Wang Y, Feng WW,Yue XJ, Chen JH, Hu XZ, Li ZF, Sheng DH, Zhang YM, Li YZ#. CRISPR/dCas9-mediated transcriptional improvement of the biosynthetic gene cluster for the epothilone production inMyxococcus xanthus.Microbial Cell Factories. 2018.
15. Zhu LP,Yue XJ, Han K, Li ZF, Zheng LS, Yi XN, Wang HL, Zhang YM, Li YZ#. Allopatric integrations selectively change host transcriptomes, leading to varied expression efficiencies of exotic genes inMyxococcus xanthus.Microbial Cell Factories. 2015.
1.2021年度山东省自然科学奖二等奖,黏细菌合成抗肿瘤化合物埃博霉素的应用基础研究,完成人:李越中,岳新晶,黎志凤
2.2023年度CULSC全国大学生生命科学竞赛(科学探究类)国家级二等奖,获奖项目:抗肿瘤化合物埃博霉素高产异源表达菌株的构建及快速筛选,指导教师
3.2024年度山东省大学生生物化学技能与创新创业大赛省级三等奖,获奖项目:抗肿瘤化合物埃博霉素首个转录激活因子的调控机制解析,指导教师
4.2024年度CULSC全国大学生生命科学竞赛(科学探究类)山东省赛区三等奖,获奖项目:利用核糖体工程技术选育埃博霉素高产菌株,指导教师