生物与医药

张正

研究员
博士/硕士生导师
0532-58631557
个人简介 科研项目 学术论文 其他介绍

教育背景

2014.09-2018.06,山东大学,微生物学,博士

2003.09-2007.06,山东大学,国家生命科学与技术人才培养基地,本科


工作经历

2021.01-至今,山东大学微生物技术研究院,研究员,“齐鲁青年学者”,博导

2020.08-2021.01,山东大学微生物技术研究院,副研究员

2018.07-2020.07,山东大学微生物技术研究院,博士后

2007.07-2014.08,微生物技术国家重点实验室,科研助理


研究方向

1.人工智能挖掘微生物功能基因资源

2.微生物生物地理学和群落生态学

3.微生物抗菌毒素-免疫蛋白系统

科研项目

1.山东省泰山学者青年专家项目,2026-2028,主持

2.国家自然科学基金面上项目,2023-2026,主持

3.科技部科技基础资源调查专项子课题,2022-2025,主持

4.山东大学“齐鲁青年学者”学科建设经费,2021-2025,主持

5.江苏省自然科学基金青年基金项目,2019-2022,主持

发表论文

Geng Y., Liu Y.*, Li P., Sun J., Jiang Y., Pan Z., Li Y. Z., &Zhang Z.*(2025). Anthropogenic activity and climate change exacerbate the spread of pathogenic bacteria in the environment.Science Advances, 11(13): eads4355.

Liu Y., Geng Y., Jiang Y., Li P., Li Y. Z.*, &Zhang Z.*(2025). Global microbial community biodiversity increases with antimicrobial toxin abundance of rare taxa.The ISME Journal, 19(1): wraf012.

Liu Y.1, Geng Y.1, Jiang Y., Sun J., Li P., Li Y. Z.*, &Zhang Z.*(2025). Global biogeography and projection of antimicrobial toxin genes.Microbiome, 13(1): 40.

Wang F., Luo J.,Zhang Z., Liu Y., Sheng D., Zhuo L., & Li Y. Z.* (2025). Differential crosstalk between toxin-immunity protein homologs divides Myxococcus nonself siblings into close and distant social relatives.mBio, 16: e03902-24.

Li D.1, Wang J.1, Jiang Y., Zhang P., Liu Y., Li Y. Z.*, &Zhang Z.*(2024). Quantifying functional redundancy in polysaccharide degrading prokaryotic communities.Microbiome, 12(1): 120.

Pan Z.1, Li D.1, Li P., Geng Y., Jiang Y., Liu Y., Li Y. Z.*, &Zhang Z.*(2024). GDPF: a data resource for the distribution of prokaryotic protein families across the global biosphere.Nucleic Acids Research, 52(D1): D724-D731.

Li D.1,Zhang Z.1*, Zhang P., Wang J., Liu Y., & Li Y. Z.* (2024). Deterministic assembly processes shaping habitat‐specific glycoside hydrolase composition.Global Ecology and Biogeography, 33(1): 189-202.

Hu W., Yang J., Wang J., Yuan S., Yue X.,Zhang Z., Zhang Y., Meng J., & Li Y. Z.* (2024). Characteristics and immune functions of the endogenous CRISPR-Cas systems in myxobacteria.mSystems, 9(6): e01210-23.

Liu Y., Liu S., Pan Z., Ren Y., Jiang Y., Wang F., Li D., Li Y. Z.*, &Zhang Z.*(2023). PAT: a comprehensive database of prokaryotic antimicrobial toxins.Nucleic Acids Research, 51(D1): D452-D459.

Li D.,Zhang Z.*, Wang J., Zhang P., Liu Y., & Li Y. Z.* (2023) Estimate of the degradation potentials of cellulose, xylan, and chitin across global prokaryotic communities.Environmental Microbiology, 25(2): 397-409.

Wang J., Pan Z., Yu J.,Zhang Z., & Li Y. Z.* (2023). Global assembly of microbial communities.mSystems, 8(3): e01289-22.

Ding P., Ming Z., Liu J., Erill I., &Zhang Z.*(2022). Microbiome and microbial informatics.Frontiers in Microbiology, 4278.

Zhang P., Zhang L., Jiang X., Diao X. T., Li S., Li D.,Zhang Z., Fang J., Tang Y. J., Wu D. L., Wu C., & Li Y. Z. (2022). Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B.Communications Biology, 5(1): 1-11.

Zhang Z.1*, Liu Y.1, Zhang P., Wang J., Li D., & Li Y. Z.* (2021). PAAR proteins are versatile clips that enrich the antimicrobial weapon arsenals of prokaryotes.mSystems, 6(6): e00953-21.

Li D., Wang J. L., Liu Y., Li Y. Z.*, &Zhang Z.*(2021). Expanded analyses of the functional correlations within structural classifications of glycoside hydrolases.Computational and Structural Biotechnology Journal, 19: 5931.

Feng Z.1,Zhang Z.1, Liu Y., Gu, J., Cheng Y., Hu W., Li Y. Z., & Han W.* (2021). The second chromosome promotes the adaptation of the genus Flammeovirga to complex environments.Microbiology Spectrum, 9(3): e00980-21.

Wang J.1, Wang J.1, Wu S.,Zhang Z.*, & Li Y. Z.* (2021). Global geographic diversity and distribution of the myxobacteria.Microbiology Spectrum, 9(1): e00012-21.

Pan Z.,Zhang Z., Zhuo L., Wan T., & Li Y. Z.* (2021). Bioinformatic and functional characterization of Hsp70s in Myxococcus xanthus.mSphere, 6(3): e00305-21.

Liu Y., Wang J.,Zhang Z., Wang F., & Li Y. Z.* (2021). Two PAAR proteins with different C-terminal extended domains have distinct ecological functions in Myxococcus xanthus.Applied and Environmental Microbiology, 87(9): e00080-21.

Zhang Z.1*, Wang J.1, Wang J., Wang J., & Li Y. Z.* (2020). Estimate of the sequenced proportion of the global prokaryotic genome.Microbiome, 8(1): 134.

Liu Y.,Zhang Z.*, Wang F., Li D., & Li Y. Z.* (2020). Identification of type VI secretion system toxic effectors using adaptors as markers.Computational and Structural Biotechnology Journal, 18: 3723-3733.

Zhang P.1,Zhang Z.1, Zhang L., Wang J., & Wu, C.* (2020). Glycosyltransferase GT1 family: Phylogenetic distribution, substrates coverage, and representative structural features.Computational and Structural Biotechnology Journal, 18: 1383-1390.

Wang J., Wang J.,Zhang Z., Li Z., Zhang Z., Zhao D., ... & Li Y. Z.* (2020). Shifts in the bacterial population and ecosystem functions in response to vegetation in the Yellow River delta wetlands.mSystems, 5(3).

Chen X. J.,Zhang Z., Li Y. J., Zhuo L., Sheng D. H., & Li Y. Z.* (2020). Insights into the persistence and phenotypic effects of the endogenous and cryptic plasmid pMF1 in its host strain Myxococcus fulvus 124B02.FEMS Microbiology Ecology, 96(3): fiaa001.

Li D., Wang J., Jin Z., &Zhang Z.*(2019). Structural and evolutionary characteristics of dynamin-related GTPase OPA1.PeerJ, 7: e7285.

Zhang P.,Zhang Z., Li Z. F., Chen Q., Li Y. Y., Gong Y., ... & Li Y. Z.* (2019). Phylogeny‐guided characterization of glycosyltransferases for epothilone glycosylation.Microbial Biotechnology, 12(4): 763-774.

Zhang Z., Wang J., Gong Y., & Li Y. Z.* (2018). Contributions of substitutions and indels to the structural variations in ancient protein superfamilies.BMC Genomics, 19(1): 1-9.

Gong Y.1,Zhang Z.1, Liu Y., Zhou X. W., Anwar M. N., Li Z. S., ... & Li Y. Z.* (2018). A nuclease‐toxin and immunity system for kin discrimination in Myxococcus xanthus.Environmental Microbiology, 20(7): 2552-2567.

Zhuo L.,Zhang Z., Pan Z., Sheng D. H., Hu W., & Li Y. Z.* (2018). CIRCE element evolved for the coordinated transcriptional regulation of bacterial duplicate groELs.Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1861(10): 928-937.

Li Y. J., Liu Y.,Zhang Z., Chen X. J., Gong Y., & Li Y. Z.* (2018). A post-segregational killing mechanism for maintaining plasmid pMF1 in its Myxococcus fulvus host.Frontiers in Cellular and Infection Microbiology, 8: 274.

Gong Y.,Zhang Z., Zhou X. W., Anwar M. N., Hu X. Z., Li Z. S., ... & Li Y. Z.* (2018). Competitive interactions between incompatible mutants of the social bacterium Myxococcus xanthus DK1622.Frontiers in Microbiology, 9: 1200.

Yue X. J.1, Cui X. W.1,Zhang Z., Hu W. F., Li Z. F., Zhang Y. M., & Li Y. Z.* (2018). Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones in Myxococcus xanthus.Applied Microbiology and Biotechnology, 102(13): 5599-5610.

Gao X.*,Zhang Z.*, Li Y., Hu H., Wang S., & Li C. (2017). A newly determined member of the meso-diaminopimelate dehydrogenase family with a broad substrate spectrum.Applied and Environmental Microbiology, 83(11).

Liu L.,Zhang Z.*, Shao C. L., & Wang C. Y.* (2017). Analysis of the sequences, structures, and functions of product-releasing enzyme domains in fungal polyketide synthases.Frontiers in Microbiology, 8: 1685.

Yue X. J., Cui X. W.,Zhang Z., Peng R., Zhang P., Li Z. F., & Li Y. Z.* (2017). A bacterial negative transcription regulator binding on an inverted repeat in the promoter for epothilone biosynthesis. Microbial Cell Factories, 16(1): 1-12.

Zhuo L.1, Wang Y.1,Zhang Z., Li J., Zhang X. H., & Li Y. Z.* (2017). Myxococcus xanthus DK1622 coordinates expressions of the duplicate groEL and single groES genes for synergistic functions of groELs and groES.Frontiers in Microbiology, 8: 733.

Peng R., Chen J. H., Feng W. W.,Zhang Z., Yin J., Li Z. S., & Li Y. Z.* (2017). Error-prone DnaE2 balances the genome mutation rates in Myxococcus xanthus DK1622.Frontiers in Microbiology, 8: 122.

Wang J.,Zhang Z.*, Chang F., & Yin D.* (2016). Bioinformatics analysis of the structural and evolutionary characteristics for toll-like receptor 15.PeerJ, 4: e2079.

Wang J.1,Zhang Z.1*, Liu J., Zhao J., & Yin D.* (2016). Ectodomain architecture affects sequence and functional evolution of vertebrate toll-like receptors.Scientific Reports, 6(1): 1-10.

Liu L.,Zhang Z.*, Shao C. L., Wang J. L., Bai H., & Wang C. Y.* (2015). Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains.Scientific Reports, 5(1): 1-12.

Wang J.1,Zhang Z.1*, Fu H., Zhang S., Liu J., Chang F., ... & Yin D.* (2015). Structural and evolutionary characteristics of fish-specific TLR19.Fish & Shellfish Immunology, 47(1): 271-279.

Wang J.,Zhang Z.*, Liu J., Li F., Chang F., Fu H., ... & Yin D.* (2015). Structural characterization and evolutionary analysis of fish-specific TLR27.Fish & Shellfish Immunology, 45(2): 940-945.

Wang Y.1, Zhang W. Y.1,Zhang Z., Li J., Li Z. F., Tan Z. G., ... & Li Y. Z.* (2013). Mechanisms involved in the functional divergence of duplicated GroEL chaperonins in Myxococcus xanthus DK1622.PLoS Genet, 9(2): e1003306.

Zhang Z.1, Xing C.1, Wang L., Gong B.*, & Liu H. (2012). IndelFR: a database of indels in protein structures and their flanking regions.Nucleic Acids Research, 40(D1): D512-D518.

Zhang Z., Huang J., Wang Z., Wang L.*, & Gao P. (2011). Impact of indels on the flanking regions in structural domains.Molecular Biology and Evolution, 28(1): 291-301.

Zhang Z., Wang Y., Wang L.*, & Gao P.* (2010). The combined effects of amino acid substitutions and indels on the evolution of structure within protein families.PLoS One, 5(12): e14316.

中国微生物学会智能计算微生物学专业委员会委员

2024年第十四届青岛市青年科技奖

Frontiers in Microbiology杂志Guest Associate Editor,Microbiome and Microbial Informatics专刊主编

2021年中国微生物学会学术年会 优秀学术报告

2021年Sino-Micro & ICMS年会Intestinal Microbiomes and Microbial Bioinformatics分会场主旨报告

2020年度山东大学微生物技术研究院“科研之星”